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Get inspired. Website only available in German.]However, Dicer proteins have never been shown to have sequence cleavage preferences.

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Thus, we characterize three Dicer-like enzymes that are involved in Paramecium development and propose a biological role for their sequence-biased cleavage products. In Parameciumeight genes encode for Dicer or Dicer-like enzymes.

Swtizerland Dicer-like enzymes have similar protein domain architecture to the Dicer of Giardia intestinalis. A Four Dicer-like Dirty girl Davos from Paramecium tetraurelia are shown schematically.

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It is important for the small RNAs to target the precise excision of those DNA elements by helping Switzeroand excision machinery. Here, we show that Paramecium Dicer-like proteins have sequence specificity for their target dsRNA, which contributes to the efficiency and precision of the DNA elimination machinery.

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Both developmental classes of small RNAs found in Paramecium contain end signature motifs. Because we were bezd in the sequence preference of the Dicer-like enzymes in an unbiased way, we tested their cleavage activity with a random hairpin RNA substrate.

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